Objective To investigate the correlation of intron 3 gene polymorphisms of interleukin-4 with genetic susceptibilities to gastric cardiac carcinoma and nongastric cardiac carcinoma in Fujian province of China. Methods Polymerase chain reaction-sequence specific primer（PCR-SSP）and Sanger sequencing were performed to determine the polymorphisms of intron 3 gene of interleukin-4 in 100 gastric cardiac carcinoma patients，130 nongastric cardiac carcinoma patients and 113 control subjects in Fujian province of China. Their correlation with the risk of gastric cardiac carcinoma and nongastric cardiac carcinoma was analyzed. Results The number of the subjects with family history of upper gastrointestinal cancer（UGIC） was significantly higher in gastric cardiac carcinoma group and nongastric cardiac carcinoma group than in control group（P＜0.05）. Family history of UGIC may increase the risk of developing gastric cardiac carcinoma and nongastric cardiac carcinoma（OR=2.738，95％CI: 1.220-6.143；OR=2.452, 95%CI: 1.122-5.361）. The overall genotype distributions of intron 3 of interleukin-4 in gastric cardiac carcinoma group and nongastric cardiac carcinoma group were significantly different from those in control group（P＜0.05）. Compared with individuals with RP1.1 genotype，individuals with RP1.2 genotype had significantly higher risk in developing nongastric cardiac carcinoma（OR=2.111，95％CI：1.172-3.803）. When stratified for gender and family history of UGIC，compared with individuals with RP1.1 genotype，individuals with RP1.2 genotype in male group（OR=2.496，95％CI：1.235-5.047） and in the group without family history of UGIC（OR=1.909，95％CI：1.020-3.573） had higher risk in developing nongastric cardiac carcinoma， and individuals with RP2.2 genotype in the group without family history of UGIC had lower risk in developing nongastric cardiac carcinoma（OR=0.496，95％CI：0.268-0.918）. Conclusion Intron 3 polymorphisms of interleukin-4 may be one of the factors that affect the risk of developing nongastric cardiac carcinoma in Fujian province of China.