Chinese Clinical Oncology

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RapidArc radiotherapy for postoperative cervical cancer:comparison with three-dimensional conformal radiotherapy

JIANG Jun,LI Li,ZHANG Liwen,LIAO Shan,HUANG Rong.
  

  1. Radiological Medicine and Public Health Institute,Medical College of Soochow University, Suzhou 215006,China
  • Received:2013-01-21 Revised:2013-03-09 Online:2013-07-31 Published:2013-07-31
  • Contact: LI Li

Abstract:

Objective To compare the differences of dose distribution in clinical target volume and organ at risk (OAR)between volumetric-modulated arc therapy(RapidArc) and conventional three-dimensional conformal radiotherapy(3D-CRT) in the radiotherapy of postoperative cervical cancer. Methods Ten postoperative patients with cervical cancer were chosen randomly. The next steps were CT scan,PTV and OAR contouring. The RapidArc plan and 3D-CRT plan were performed for each patient with the prescribed dose 50Gy,respectively. Homogeneity index (HI),conformity index (CI),maximum dose(PTVmax),minimum dose(PTVmin),mean dose(PTVmean) of PTV and irradiated volume of OARs were calculated and the results were compared. Results Conformity index (CI) of PTV and PTV Dmean in RapidArc plan were better than those in 3D-CRT plan with statistically significant difference(P<0.05). Compared with 3D-CRT plans,V20 of the left and right femoral head,V50 of the bladder and V40,V50 of rectum in RapidArc plans all reduced and the differences were statistically significant (P<0.05). While there were no significant difference on the PTV Dmax,PTV Dmin,HI and OARs(V10,V20,V30,V40,V50 of the small bowel,V10,V20,V30 of the rectum,V10, V20,V30,V40 of the bladder,V10,V30,V40,V50of the left and right femoral head) between 3D-CRT and RapidArc group (P>0.05). Conclusion RapidArc plans are better than 3D-CRT plans in CI of PTV and PTV Dmean in the radiotherapy of postoperative cervical cancer. Meanwhile,compared with 3D-CRT plans,there are more advantages in sparing the OAR in RapidArc plans.

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