Abstract: Objective To investigate the expression of survivin,Ki-67 in the primary non-Hodgkin's lymphoma (NHL) in oral and maxillofacial region and the relationship between the expression of survivin,Ki-67 and histological phenotypes of NHL.Methods The expression of survivin and Ki-67 was determined by En Vision immunohistochemical technique in 39 cases with NHL in oral and maxillofacial region and 20 cases with lymphadenitis as the control.Results The positive expression rates of survivin and Ki-67 in NHL in maxillofacial region were 66.7%（26/39）and 71.8%（28/39）,significantly higher than 20.0%(4/20) and 10.0%(2/20) in lymphadenitis tissue(P<0.05). The positive expression rates of survivin and Ki-67 in nodal and extra-nodal NHL were higher than those in the control group(P<0.05). There were statistical differences between survivin, Ki67 expression in nodal and extra-nodal NHL (P＞0.05). The expression of survivin and Ki67 in highly malignant NHL was higher than that in lowly malignant (P<0.05). The expression of survivin (r= 0.471, P=0.018) and Ki-67 (r=0.691, P=0.000) was positively related to the level of histological phenotypes.Conclusion The survivin and Ki-67 expression play important roles in the occurrence and development of NHL in oral and maxillofacial region. They can be regarded as the prognostic indexes.