Abstract: Treatment of advanced breast cancer is aim to prolong survival time and improve the quality of life. Patients with metastatic breast cancer who obtain clinical benefit by means of firstline treatment are in stable condition， through making use of highefficiency， low toxicity, convenient drugs of maintenance treatment so as to extend progressionfree survival as far as possible and relieve sickness， delay progress and prolong survival time. This article from maintenance treatments concept and theory， treatment mode， drug research discusses maintenance treatment of advanced breast cancer and introduces the relevant research progress.