Abstract: Objective To investigating the expression of chloride intracellular channel 1（CLIC1）in endometrioid adenocarcinoma tissue， and analyze the relationship of its expression with clinicopathologic features. Methods The expression of CLIC1 among 100 cases of endometrioid adenocarcinoma and 50 cases of normal endometrioid tissues were tested by SP method，and the correalation of the expression of CLIC1 in endometrioid adenocarcinoma with clinicopathologic features was further studied. Results The positive rate of CLIC1 was 63.0％ in endometrioid adenocarcinoma，higher than 22.0％ of normal endometrioid tissue（P＜0.05）. The expression of CLIC1 was related with pathological staging and lymph node metastasis（P＜0.05），but not with age，menopause，histological grade and depth of invasion（P＞0.05）.
Conclusion The higher expression of CLIC1 may accelerate the occurrence and development of endometrioid adenocarcinoma.