Abstract: Objective To investigate the value of clinicopathologic characteristics， serum tumor markers and inflammatory factors in judging the prognosis of advanced gastric cancer. Methods Two hundred and forty-eight gastric cancer patients with stage ⅢⅣ undergoing operation in Nanjing Drum Hospital between 2008 and 2013 were included in this study. The postoperative survival rate was calculated by KaplanMeier method. Univariate analysis of prognosis were used by Logrank method. Multivariable analysis of prognosis was used by Cox proportional hazad regression model. Results In univariate analysis， tumor size， T staging， N staging， Lauren classification， vascular invasion， surgical modalities， carcinoembryonic antigen（CEA）， carbohydrate antigen（CA）724， CA199， CA125， Glasgow prognostic score（GPS）， neutrophil to lymphocyte ratio（NLR） and platelet to lymphocyte ratio（PLR） were associated with overall survival in patients with advanced gastric cancer. Multivariate analysis revealed that palliative surgery， stage of T4b， CEA， CA199 were independent risk factors of poor prognosis. Conclusion Palliative surgery， stage of T4b， CEA， CA199 are independent risk factors of patients with advanced gastric cancer.