Abstract: Objective To investigate the expressions of 14-3-3ζ and E-cadherin in resected stageⅢ lung adenocarcinoma and their clinical significance.
MethodsThe expressions of 14-3-3ζ and E-cadherin in resected stage Ⅲ lung adenocarcinoma tissues obtained from 59 patients and 43 specimens of corresponding adjacent normal alveolus tissues using immunohistochemistry，and their correlations with clinicopathological characteristics and prognosis of patients were analyzed. The overall survival（OS） of patients was estimated using the KaplanMeier method. The factors affecting the prognosis of stage Ⅲ lung adenocarcinoma patients were analyzed by Cox multivariate survival analysis. ResultsThe high-level expression rate of 14-3-3ζ in lung adenocarcinoma tissue was 57.63％（34／59）， higher than 30.23（13／43） of paired adjacent normal alveolus tissues with statistical difference（P＜0.05）. The high-level expression rate of E-cadherin in lung adenocarcinoma tissue was 67.79％（40／59）， lower than 72.09％（31／43） of paired adjacent normal alveolus tissues without statistical difference（P＞0.05）. Both of 14-3-3ζ and E-cadherin expressions were correlated to differentiation（P＜0.05）.Positive correlation was observed between expressions of 14-3-3ζ and E-cadherin （r=0.351，P=0.015）.The median OS of 59 patients was 29.90 months. The median OS of patients with 14-3-3ζ and E-cadherin high-level expression both were 52.63 months， higher than 16.93 months of patients with lowlevel expression（P＜0.05）. Multivariate survival analysis showed that 14-3-3ζ was independent prognostic indicator for resected stage Ⅲ lung adenocarcinoma patients（P＜0.05）. Conclusion The expressions of 14-3-3ζ and E-cadherin shows a good correlation in lung adenocarcinoma tissues. Detecting the expressions of these two proteins may give a clue on prognosis in patients with stageⅢ lung adenocarcinoma.