Chinese Clinical Oncology

• 论著 • Previous Articles     Next Articles

Expression of Fn14 in esophageal squamous cell carcinoma and its clinical significance

LIU Kai,LI Xiaofei, ZHANG Zhipei, WANG Wuping,SUN Ying.

  

  1. Department of Thoracic Surgery, Xianyang Central Hospital, Xianyang 712000, China
  • Received:2015-03-04 Revised:2015-05-14 Online:2015-07-31 Published:2015-07-31

Abstract: Objective To investigate the expression of fibroblast growth factor-inducible 14(Fn14)in esophageal carcinoma and its relationship with clinical data and prognosis of patients with esophageal squamous cell carcinoma(ESCC). Methods In this study, Fn14 expression in tumor tissues was assessed using immunohistochemical(IHC)methods in 118 patients with resected ESCC. The association of Fn14 expression with clinicopathological parameters were also evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of Fn14 expression on survival. Results It showed that Fn14 was expressed in 51.7% (61/118) and 4.2% (5/118) of cancer lesions and corresponding adjacent non-cancerous tissue, respectively (P<0.001). Fn14 expression was significantly correlated with lymphatic metastasis and TNM stage(P<0.001). The median overall survival of Fn14 positive expression patients and negative expression patients were 23 months(95%CI:17-29 months) and 54 months(95%CI:50-58 months) with statistical significance (P<0.001). Multivariate analysis indicated that in addition to the T and N stage, Fn14 expression may also be an independent prognostic factor in ESCC (HR=1.51, 95%CI:1.02-2.24, P=0.022). Conclusion Fn14 expression is of clinical significance and can serve as a prognostic biomarker in ESCC.

No related articles found!
Viewed
Full text
148
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 148

  From Others local
  Times 4 144
  Rate 3% 97%

Abstract
80
Just accepted Online first Issue
0 0 80
  From Others
  Times 80
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!