Abstract: Objective To explore the treatment and prognosis of sinonasal neuroendocrine carcinoma（SNEC）. Methods A retrospective analysis of 7 patients with SNEC from May 2012 to July 2014 was performed. All the patients were male and age from 39 to 61. The main symptoms were nasal obstruction，headache, and facial swelling and pain. Three patients were in IVA stage，three were in IVB stage and one unknown. One patient underwent preoperative chemotherapy and surgery，one with preoperative chemoradiotherapy and surgery，and five patients received radical radiotherapy in combination with chemotherapy. Results Partial remission was observed in all 7 patients after treatment and complete remission was observed in 2 patients during follow-up. The follow-up ranged from 10.56 months. One patient died of distant metastasis，and the remaining 6 patients were still alive in followup.The side effects included oral mucositis，myelosuppression and transaminase elevation. ConclusionSNEC is rare and highly malignant in clinic without typical clinical presentation. Comprehensive treatment based on radiotherapy may improve prognosis of patients with local advance.