Chinese Clinical Oncology

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Correlation analysis between the expression of B7-H3 and the level of macrophages infiltration in hepatocellular carcinoma tissues

KANG Fubiao,WANG Ling,WANG Yan,PENG Huanyan,SUN Dianxing.   

  1. Liver Disease Diagnosis and Treatment Center of PLA, Bethune International Peace Hospital
  • Received:2016-03-31 Revised:2016-05-08 Online:2016-07-30 Published:2016-07-30
  • Contact: SUN Dianxing

Abstract: Objective To investigate the relationship between the expression of B7-H3 and the level of tumor-associated macrophages(TAMs) infiltration in hepatocellular carcinoma(HCC) tissues. MethodsThe expression level of B7-H3 was detected by immunohistochemistry and quantitative Real-time PCR in 116 HCC tissues. Immunohistochemistry also was used to detect CD68 expression. Then the relationship between B7-H3, CD68 expression and clinicopathologic features was analyzed. Results Among the 116 cancer tissues, the high expression rate of B7-H3 was 79.3%(92/116); and patients with the low, middle, high level of TAMs infiltration were 21, 49 and 46 cases. The expression of B7-H3 was related to TNM stage, vascular invasion and microsatellite lesions formation(P<0.05); The level of TAMs infiltration was related to TNM stage, vascular invasion, lymph node metastases and microsatellite lesions formation(P<0.05). The mRNA level of B7-H3 was significantly correlated with the level of TAMs infiltration (r=0.473,P<0.001). ConclusionThe expression level of B7-H3 is positively correlated with the level of TAMs infiltration in HCC tissues, and they may contribute to the oncogenesis and progression of HCC.

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