Abstract: Objective To explore the short-term curative effect and influencing factors of non-small cell lung cancer（NSCLC）with osseous metastasis through zoledronic acid combined with radiotherapy. Methods In this study，106 NSCLC patients with osseous metastasis in our hospital from May 2013 to May 2015 were randomly divided into the combination group and the control group with 53 cases in each group. The control group received radiotherapy alone，and the combination group were treated with zoledronic acid on the basis of radiotherapy. The pain relief statuses of two groups were compared. The factors influencing the short-term pain relief were analyzed using multivariate Logistic regression analysis. The factors influencing the short-term pain relief of two kinds of treatment methods were analyzed using univariate Logistic regression analysis. Results The effective rate of combination group was 92.5% （49/53）， higher than 69.8%（37/53）of control group（P=0.003）. Multivariate Logistic regression analysis showed that treatment was the independent factor affecting the relief of bone pain in NSCLC with bone metastasis， and the difference was statistically significant （P<0.05）. The univariate Logistic regression analysis showed that patients with CT imaging manifestations of osteolytic lesions in combination group had a better curative effect than in the control group，and the incidence of skeletal-related events was also lower in combination group than the control group（P<0.05）. Conclusion Zoledronic acid in combination with radiotherapy has better clinical curative effect in treatment of NSCLC with osseous metastasis，worth promoting on clinical.