Abstract: Objective To investigate the clinical characteristics and prognostic factors of patients with angioimmunoblastic T-cell lymphoma （AITL）. Methods The clinical data of 39 patients with AITL admitted to the First Affiliated Hospital of Anhui Medical University from February 2009 to June 2016 were collected. All patients were treated by combined chemotherapy， and 29 of them received standard CHOPbased treatment. The response to chemotherapy was assessed after 2 cycles. Factors associated with overall survival were analyzed univariately by KaplanMeier method and Log-rank test. Results The median age was 62 years old for 39 patiens， and the maletofemale was 2.5∶1. Ann Arbor staging showed that 30 cases were stage Ⅲ-Ⅳ. The ECOG score＞1 was found in 13 cases， 29 cases had elevated lactic dehydrogenase（LDH）， 20 cases had increased Beta 2-microglobulin（β2-MG）.The low level of albumin was found in 19 cases，19 cases had increased lymphocyte，12 cases had＞1 extranodal involvement， 16 cases had serous cavity effusion， Ki-67≥50％ was found in 11 cases， 33 cases had an international prognostic index （IPI） score≥2. Of the 39 cases， 9 cases had complete response and 14 cases had partial response. The overall response rate was 58.9％. The expected 1-，2- and 3-year overall survival rate was 81％， 59％ and 40％， respectively. The median overall survival was 27 months（95％CI：15.139-38.861）and the median progressionfree survival was 9 months（95％CI：1.317-16.683）. Univariate analysis showed that ECOG score＞1， extranodal involvement＞1 site， serous cavity effusion and Ki-67≥50％ were adverse prognostic factors of AITL（P＜0.05）. Conclusion AITL is highly aggressive with poor prognosis. ECOG， extranodal involvement， serous cavity effusion and Ki-67 may be prognostic factors of AITL.