Chinese Clinical Oncology

• 论著 • Previous Articles     Next Articles

Design of normal tissue complication probability(NTCP)and tumor control probability(TCP)calculation program for intensity modulated radiotherapy for nasopharyngeal carcinoma based on EUD

LU Hong,LI Bing,SONG Wei,YU Dahai,ZHAO Di,ZHANG Biyun   

  1. Department of Radiotherapy,Jiangsu Hospital of Traditional Chinese Medicine,Nanjing 210029,China
  • Received:2016-10-31 Revised:2017-01-12 Online:2017-04-30 Published:2017-04-30
  • Contact: LI Bing

Abstract:

Objective To calculate the normal tissue complication probability(NTCP)and the tumor control probability(TCP)of intensity modulated radiotherapy(IMRT)plan for nasopharyngeal carcinoma(NPC)by using an equivalent uniform dose(EUD). Methods As a high-level technical computing language with friendly interface and mathematical properties,Matlab was chosen to implement the EUD-based Lyman-Kutcher-Burman NTCP mathematical model and Schultheiss TCP logistic model. The normal tissue and target dose-volume histogram(DVH)of three patients with NPC were obtained from Elekta precise treatment planning system. The necessary parameters for the model were clearly defined. Results The computer code is presented and saved as a Matlab program. The EUD and NTCP values of four normal tissues from three NPC patients were generated and the TCP values were further gained. Conclusion The model has an excellent ability in fitting the normal structures tolerance values in this study. It is helpful for clinicians to select safer and more effective treatment plans. In future,the program will be modified and tested in radiotherapy for prostate and lung cancer.

No related articles found!
Viewed
Full text
520
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 520

  From Others local
  Times 6 514
  Rate 1% 99%

Abstract
346
Just accepted Online first Issue
0 0 346
  From Others
  Times 346
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!