Abstract:

Anti-human epidermal growth factor receptor-2（HER-2）therapies improved the prognosis of patients with HER-2 positive breast cancer. Trastuzumab，pertuzuma，lapatinib and T-DM1 are the major choices for these patients at present. Cardiotoxicity is one of the side effects of anti-HER-2 drugs and it puts patients at a risky position，which contains various manifestations and can be prevented and cured. Having knowledge of its symptoms，probabilities as well as its preventions and treatment helps to the process of anti-HER-2 treatment.