Abstract: Incidence of gastric cancer in China is almost half of the morbidity in the world. Because the early clinical symptoms are not typical and early gastric cancer screening is not enough in China， the majority of patients diagnosed with advanced gastric cancer. Traditional chemotherapy was the mainly treatment options for advanced gastric cancer， but the curative effect of chemotherapy was still limited and reached the bottleneck. With the research development of tumor molecular biology， molecular-targeted therapy for the treatment of advanced gastric cancer has brought a new dawn and hope. This thesis summarizes the new progression in targeted therapy of gastric carcinoma in recent years， analyzes the drug efficacy and safety， and provides some references for clinical treatment.