Abstract: Objective To investigate the effect of different working experience of radiation therapist on intensity modulated radiation therapy in elderly patients with stage Ⅲ non-small cell lung cancer（NSCLC）. Methods A total of 160 elderly patients with stage Ⅲ NSCLC from August 2015 to August 2017 were enrolled. Depending on the working years of radiation therapist， all patients were randomly divided into ＜5 years group（n=80） and ≥5 years group（n=80）. All patients received concurrent chemoradiotherapy. The radiation dose was 60-70 Gy／30-35 f， 5 fractions per week. The drugs of chemotherapy included paclitaxel， docetaxel， pemetrexed， gemcitabine， cisplatin and carboplatin， et al. Results In ＜5 years group， there were 8 cases（10.0％） of complete remission（CR）， 48 cases of partial remission（PR）， 16 cases（20.0％） of stable disease（SD） and 8 cases（10.0％） of progression（PD）.The response rate（RR） was 70.0％. In ≥5 years group， there were 8 cases（10.0％） of CR， 68 cases（85.0％） of PR and 4 cases（5.0％） of PD. The RR was 95.0％. The difference of RR between the two groups had statistical significance（P＜0.05）. The stable and improve rate of quality of life was 80.0％ in ＜5 years group， lower than 92.5％ of ≥5 years group with statistical difference（P＜0.05）. Compared with ＜5 years group， the side effects in ≥5 years group were mild， but 3-4 grade of leucopenia and acute or long-term radio pneumonia between the two groups had no statistical differences（P＞0.05）. Conclusion The patients with stage Ⅲ NSCLC who received operation of radiation therapist with≥5 working years had better short-term effect and quality of life.

Key words: Non-small cell lung cancer（NSCLC）, Radiation therapist, Elder, Intensity modulated radiation therapy