Abstract: ObjectiveTo explore the expression of receptor tyrosine kinase EphB6 in gastric cancer tissues and its relationship with clinicopathological characteristics. 
MethodsThe expression of EphB6 in 152 gastric cancer and paired adjacent normal tissues was detected by immunohistochemistry. The relationship between the expression of EphB6 and clinicopathological parameters was analyzed. ResultsIn 152 cases of gastric cancer, the low expression of EphB6 was found in 66 cases （43.4%）， moderate expression in 54 cases（35.5％）， and high expression in 32 cases （21.1％）. The expression of EphB6 was high expressed in adjacent normal tissues. The expression of EphB6 was associated with differentiation， lymph node metastasis and TNM stage （P＜0.05）， but not related to age， gender， tumor location and depth of tumor invasion （P＞0.05）. ConclusionThe expression of EphB6 protein was decreased in gastric cancer and related to lymph node metastasis. It may be a potential marker to predict the metastasis of gastric cancer.

Key words: Gastric cancer, EphB6, Receptor tyrosine kinase, Metastasis