Abstract: Thyroid tumor is one of the most common endocrine tumors. Recent epidemiological studies show that the incidence of thyroid carcinoma is increasing rapidly. Erythropoietin producing hepatocyte （Eph） gene as the largest family of tyrosine kinase receptors， is found to be involved in many physiological and pathological processes， and its role in tumorigenesis is attracting more and more attention. Eph receptors are overexpressed in many human malignancies and are associated with tumor growth， invasion， metastasis， and angiogenesis. Research shows that the expression level of Eph receptor in thyroid carcinoma is significantly increased, which plays an important role in the occurrence， development and metastasis of thyroid carcinoma and has broad prospects for early diagnosis and treatment of thyroid carcinoma.

Key words: Thyroid carcinoma, Erythropoietin producing hepatocyte （Eph）, Targeted therapy