Abstract: The patientderived tumor xenograft （PDTX） model is developed by implanting fresh tumor tissues into immunodeficient mice and relying on the microenvironment provided by the mice. This model retains the principal pathophysiological characteristics， histological and phenotypic characteristics of donor tumors， maintains the matrix and stem cell composition of tumor cells， and replaces patients with preclinical studies to find a more reliable anticancer strategy. The incidence and mortality of gastrointestinal system tumors is extremely high. Now， more and more domestic and foreign experiments have been developed to build digestive system PDTX models and use them for the study of the corresponding tumors. This paper reviewed the latest application of PDTX model in gastrointestinal system tumor research， and the future development of tumor therapy is discussed and forecasted.

Key words: Gastrointestinal system tumors, Patientderived tumor xenograft model（PDTX model）, Immunodeficient mice, Xenograft, Targeted drugs