Abstract: ObjectiveTo investigate the effect of whole course nutritional support on acute radiation response， treatment tolerance and curative effect of cervical cancer patients. 
MethodsNinetyeight locally advanced cervical patients with radical concurrent chemoradiotherapy and nutritional risk screening2002 scoring more than 3 points were divided randomly into two groups： 46 cases in the experimental group （used whole course nutritional support combined concurrent chemoradiotherapy） and 52 cases in the control group （only concurrent chemoradiotherapy）. The body mass index （BMI）， albumin （ALB）， prealbumin （PA） and quality of life score （KPS score） were recorded before and after radiotherapy， and the acute radioactivity， treatment tolerance （the total course of radiotherapy， the interruption rate of radiotherapy， the number of chemotherapy） and the curative effect were evaluated at the end of the radiotherapy. 
ResultsIn the experimental group， the treatment was completed according to the plan， only 13 cases had been interrupted by radiotherapy， and 45 of the 52 cases in the control group had been treated with radiotherapy interruption， of which 9 cases failed to complete the radiotherapy according to the plan. The rate of radiotherapy in the experimental group was lower than that of the control group （2826％ vs. 8654％）， and the number of chemotherapy in the experimental group was more than that of the control group （496 ± 021 vs. 431 ± 073）. The total day of radiotherapy in the experimental group was lower than that of the control group （6313 ± 647 vs. 8523 ± 1928）， and the difference was statistically significant （P＜005）. The ALB and PA of the experimental group were better than those of the control group after radiotherapy （P＜005）. The incidence and incidence of acute radiation proctitis， acute gastrointestinal reaction and myelosuppression in the experimental group were lower than those in the control group （P＜005）. The total effective rate （RR） of the experimental group was significantly higher than that of the control group （9348％ vs. 7442％）， and the difference was statistically significant （P＜005）. 
ConclusionTotal nutritional support can significantly reduce the acute radiation reaction in patients with radical cervical cancer， improve the patients nutritional status and quality of life， and improve the therapeutic tolerance and radiotherapy effect.

Key words: Cervical Cancer, Nutrition, Radiotherapy, Tolerance, Efficacy