Abstract: Objective To explore the expression and clinical value of microRNA (micro RNA, miR)-183 and cell cycle G1 to S phase transition 1 (GSPT1) in cervical cancer. Methods From January 2014 to December 2016，91 patients with cervical cancer who were surgically treated were enrolled. Fluorescence quantitative PCR was used to detect the expression of miR183 and GSPT1 in 91 cases of cervical cancer and adjacent tissues. The correlation between the expression of miR-183 and GSPT1 in cancer tissues were analyzed by linear correlation analysis. Bioinformatics was used to predict the site of interaction between the two. The relationship of miR-183, GSPT1 expression with clinicopathological parameters as well as prognosis were statistically analyzed. Results The expression of miR183 in cancer tissues (0.521±0.065) was lower than that in adjacent tissues (1.241±0.286), and the difference was statistically significant (P=0.000); the expression of GSPT1 in cancer tissues (2.034±0.374) was significantly higher than that in adjacent tissues (0.708±0.157) , and the difference was statistically significant (P=0.000). There was a significant negative correlation between the expression of miR-183 and GSPT1 in cancer tissues (r=-0.621, P=0.001). Bioinformatics predicted that GSPT1 mRNA between base 981 to 987 had an interaction site with miR-183.The expression of miR-183 and GSPT1 was related to FIGO stages, tumor differentiation, depth of muscle invasion and lymph node metastasis (P<0.05), but not with pathological types and age (P>0.05). The 1-, 3-, and 5-year disease-free survival rates of 91 cervical cancer patients were 86.8%, 73.6% and 61.5%, respectively. The 1-, 3- and 5-year disease-free survival rates in the high miR-183 expression group were 91.1%, 86.6% and 80.0% respectively, which were better than 82.6%, 60.9% and 43.5% in the low miR-183 expression group (P=0.012). The 1-, 3- and 5-year diseasefree survival rates in the high GSPT1 expression group were 86.0%, 60.4% and 39.5%, respectively, lower than 87.5%, 85.4% and 81.2% in the low GSPT1 expression group (P=0.007). Conclusion The expression of miR-183 in cervical cancer is decreased, and the expression of GSPT1 is increased. The two promotes the tumor progression of cervical cancer, which are expected to be prognostic markers for cervical cancer.

Key words: Cervical cancer, MicroRNA-183, Cell cycle G1 to S phase transition 1, Prognosis