Chinese Clinical Oncology

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Expressionandclinicalsignificanceofc-kitinnasopharyngealcarcinomaontissuemicroarrary

  

  • Received:2008-10-26 Revised:1900-01-01 Online:2009-02-25 Published:2009-02-25

Abstract: 【Abstract】 Objective:c-kitproteinplaysanimportantroleincarcinogenesis,progressionoftumors,anditisatargetofimatinib.Thestudywastoinvestigatetheexpressionandclinicalsignificanceofc-kitinnasopharyngealcarcinoma(NPC)andevaluatethepossibilityoftreatmentwithimatinib.Methods:Formalinfixedandparaffinembeddedspecimensof153nasopharyngealcarcinomasand165normalepitheliumofnasopharyngealcavitywerestainedbytissuemicroarraytechnique.Among153nasopharyngealcarcinomapatients,42hadtheclinicaldata,includinggender,age,stageandsurvivaldatas.Results:Theresultsshowedthat373% (57/153)ofNPCbiopsysampleswerepositiveforc-kit,whileonly48% (8/165)ofnormalnasopharyngealepitheliumsamplesstainedpositively(P=0.000).c-kitexpressiondidnotcorrelatewithgender,age,clinicalstage,yetcorrelatedwithpoorlocalregionalfailurefreesurvival(P<0.05),andapproximatelycorrelatedwithadvancedTclassification(P=0.067).Conclusion:Ourresultssuggestthatc-kitoverexpressionmaybefoundsignificantlymorefrequentlyinNPCthaninnormalnasopharyngealcavitytissue,anditcorrelateswithpoorlocalregionalfailurefreesurvival.Moreover,thoseresultsprovideafoundationtoinvestigateimatinibtherapyinNPCpatients

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