Abstract: Objective To study the expression of livin and CD3+T lymphocytes infiltration in cutaneous squamous cell carcinoma（CSCC），and observe their possible role in the pathogenesis of CSCC. Methods The expression of livin and CD3+T lymphocytes infiltration were detected with immunohistochemical SP method in 40 CSCC tissues and 10 normal skin tissues. The relationships among livin， CD3+T lymphocytes and the clinic pathologic characters of CSCC were analyzed.
Results The positive rate of livin in CSCC was 70.0％（28／40），while normal skin tissue did not express livin. The number of CD3+T lymphocytes in normal skin samples was 8.70±2.25，while it was 21.87±5.21 in CSCC examples，showing significant differences（P=0.000）. The positive rate of livin and the number of CD3+T lymphocytes were correlated with the tumor histological grade and lymph node metastasis（P＜0.05），but they had no correlation（r=0.015，P=0.926）.
Conclusion Livin can be used for evaluating the malignant degree of CSCC and predicating the prognosis. The expression of CD3+T lymphocytes may be useful in estimating the local immune status and biological behaviors, and predicting the prognosis of CSCC.