临床肿瘤学杂志

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CD109、HMW-CK、Vimentin、p63和AR在基底细胞样乳腺癌中的表达及其临床意义

侍朋举1,蔡海峰2,牛凤玲2,赵燕会1,赵刚1   

  1. 1 063000河北唐山唐山市第二医院普通外科 2 063000河北联合大学附属肿瘤医院乳腺外科
  • 收稿日期:2012-04-28 修回日期:2012-08-28 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 赵刚

Expressions of CD109,HMW-CK,vimentin,p63 and AR in basallike breast cancer

SHI Peng-ju,CAI Hai-feng,NIU Feng-ling,ZHAO Yan-hui,ZHAO Gang   

  1. General Surgery,the Second Hospital of Tangshan,Tangshan 063000,China
  • Received:2012-04-28 Revised:2012-08-28 Online:2012-10-31 Published:2012-10-31
  • Contact: ZHAO Gang

摘要: 目的 探讨CD109、高分子量细胞角蛋白(HMW-CK)、波形蛋白(Vimentin)、p63和雄激素受体(AR)在基底细胞样乳腺癌(BLBC)中的表达及其与临床病理特征的关系。方法 将ER、HER-2均阴性,CK5/6和/或EGFR阳性表达者定义为BLBC,采用免疫组化SP法检测CD109、HMW-CK、Vimentin、p63和AR在86例BLBC、57例管腔细胞型(Luminal)乳腺癌和33例HER-2 过表达型乳腺癌中的表达情况。结果 CD109在BLBC、Luminal型乳腺癌和HER-2 过表达型乳腺癌组织中的阳性表达率分别为61.6%,8.8%和9.1%,HMW-CK分别为90.7%、26.3%和33.3%,AR分别为31.4%、71.9%和42.4%,组间差异均有统计学意义(P<0.05);Vimentin的阳性表达率分别为57.0%、42.1%和51.5%,p63 分别为31.4%、29.8%和24.2%,组间差异均无统计学意义(P>0.05)。在BLBC中CD109、HMW-CK、Vimentin和p63的表达与临床病理特征无关(P>0.05),而AR的表达与组织学分级有关(P<0.05)。结论 CD109和HMWCK是诊断BLBC的特异性标记物,而Vimentin和p63无诊断意义,AR表达缺失与BLBC的侵袭和恶性表型有关。

Abstract: ObjectiveTo investigate the expressions and significance of CD109, high molecular weight cytokeratin(HMW-CK),vimentin,p63 and antrogen receptor(AR) in basal-like breast cancer(BLBC). Methods ER and PR-negative and CK5/6 and/or EGFR-postive expression was defined as BLBC. Immunohistochemical method was used to determine the expressions of CD109,HMW-CK,vimentin,p63 and AR in 86 cases of BLBC,compared with 57 cases of luminal type and 33 cases of HER-2 over-expressed breast cancer. Results The positive rates of CD109 were 61.6%,8.8% and 9.1% in BLBC,luminal type and HER-2 over-expressed breast cancer,while HMW-CK were 90.7%,26.3% and 33.3%,and AR were 31.4%,71.9% and 42.4%. There was significant difference among them(P<0.01). The positive rates of vimentin was 57.0%,42.1% and 51.5%,and p63 were 31.4%,29.8% and 24.2% respectively. The difference was not significant among them(P>0.05). The expression of CD109,HMW-CK,vimentin and p63 were not correlated to age,tumor size,histological grade and lymphadenopathy. AR was correlated to histological grade in BLBC.
Conclusion CD109 and HMW-CK are the specific markers for the diagnosis of BLBC,while vimentin and p63 are not. The lack of AR expression in BLBC is related to invasion of tumor and malignant phenotype.

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