Abstract: Objective To describe clinical data and characteristics of diagnosis and treatment in children and adolescents patients with pituitary adenoma. Methods From 1989 to 2010， 74 children and adolescents patients with pituitary adenoma were analyzed retrospectively. Results In the 74 patients， 62.2％ of the tumors occurred in postpubertal age， and the average age of onset was 17.7 years old. The ratio between male and female was 1：185. The diameter of tumor was 0.4-6.0cm. Twentyfour cases invaded cavernous sinus， including 14 males and 10 female. The prolactinomas， nonfunctional adenomas， adrenocorticotropic hormone adenomas and growth hormone adenomas were 43 cases（58.1％），16 cases（21.6％），10 cases（13.5％） and 5 cases（6.8％）， respectively. There were 14 male and 10 female adenomas were invasive. In the prolactinomas， there were 9 male and 34 female. The most common presenting features were endocrinopathy and visual disturbances. All the patients treated with microsurgery， only 9 patients （12.2％） were received dopamine agonists treatment before operation； some patients proceeded postoperative bromocriptine or radiotherapy. Forty-seven cases were followed up， 6 relapsed patients were received surgery again. Twenty-nine patients in 32 recovered or improved from visual disturbances. Conclusion Children and adolescents patients with pituitary adenoma used to appear in postpubertal age， the ratio between male and female was different in various types of pituitary adenoma. Dopamine agonists using in treating prolactinomas should be further recommended in children and adolescents. The combination of dopamine agonists and surgery， as well as radiotherapy when indicated， can achieve good efficacy in the management of pituitary neoplasm.