Abstract: Objective To observe the effect of alginate dressing on hemostasis after peripherally inserted central catheter（PICC）. MethodsA total of 120 patients undergoing PICC cathetering were randomly divided into trial group（n=60） and control group（n=60）. All 120 patients were treated with a tampon oppressed on the spot of puncture and covered with a transparent dressing， while 60 patients in the trial group were covered with a twofolded alginate dressing additionally. The bleeding conditions were compared between the two groups in 24 hours after PICC cathetering. ResultsBleeding was observed in 16 patients in the trial group （16.7％）； and the frequency of bleeding degree of mild， moderate and severe were 13.3％， 10.0％ and 3.3％ respectively. In the control group， bleeding was observed in 55 patients， and frequency of bleeding degree of mild， moderate and severe were 41.6％， 33.3％ and 16.7％ respectively. The average times of dressing changing in trail group and control group were 1.1 and 2.2. There were significant differences between two groups（P＜0.05）. Conclusion Alginate softfills has a definite hemostasis effect after PICC cathetering, so as to reduce dressing changing times.