Abstract:

Objective To observe the efficacy and adverse effects of simultaneous continuous infusion of fluorouracil（5-FU） and disodium folinate（Na-FA） combined with oxaliplatin comparing to mFOLFOX6 regimen in metastatic colorectal cancer， and to evaluate the feasibility of calcium folinate（Ca-FA） substituted by Na-FA. MethodsA total of 54 patients with measurable metastatic colorectal cancer for whom had no previous FOLFOX treatment， were received infusion of disodium folinate and fluorouracil simultaneously regimen（group Na-FA，n=30） and mFOLFOX6 regimen（group Ca-FA， n=24）. The regimens were taken as follow， group NaFA： oxaliplatin 85 mg／m2 iv d1， 5-FU 0.4 g／m2 bolus d1， and 5-FU 2.4g／m2 mixed with Na-FA 0.4g／m2 infusion 46 hours. Group Ca-FA： oxaliplatin 85mg／m2 iv d1， Ca-FA 0.4g／m2 iv d1， 5-FU 0.4g／m2 bolus d1， and 5-FU 2.4g／m2 infusion 46 hours. Fourteen days was a cycle for both 2 groups. The short term effects and safety of the two groups were evaluated according to the RECIST entity tumors evaluation criteria and anticancer drugs common toxicity grading criteria after 4 cycles. Results There were 3 CR， 13 PR and 10 SD in group Na-FA， and the response rate and disease control rate were 53.3％ and 86.7％； there were 1 CR， 11 PR and 9 SD in group Ca-FA， and the response rate and disease control rate were 50.0％ and 87.5％. There was no significant difference in the two groups. The common side effects were grade 12 gastric reactions， grade 1-2 myelosuppression and grade 12 hair loss. The incidence rates of side effects were no statistical difference between the two groups. Conclusion Continuous infusion of disodium folinate and 5-FU simultaneously for patients with colorectal cancer is safe， effective and convenient. As the result， calcium folinate can be substituted by disodium folinate in mFOLFOX regimen.