临床肿瘤学杂志

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EML4-ALK阳性表达非小细胞肺癌患者的临床特征及治疗现状

孙霞,魏嘉,刘宝瑞   

  1. 210008 南京 南京医科大学鼓楼临床医学院 南京大学医学院附属南京市鼓楼医院肿瘤中心
  • 收稿日期:2012-08-03 修回日期:2012-09-28 出版日期:2013-01-31 发布日期:2013-01-31
  • 通讯作者: 刘宝瑞

Clinicopathologic characteristics and treatment of non-small cell lung cancer with EML4-ALK fusion gene

SUN Xia,WEI Jia,LIU Baorui   

  1. Drum Tower Medical College of Nanjing Medical University,the Comprehensive Cancer Center,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China
  • Received:2012-08-03 Revised:2012-09-28 Online:2013-01-31 Published:2013-01-31
  • Contact: LIU Baorui

摘要: 棘皮动物微管相关类蛋白4(EML4)与间变性淋巴瘤激酶(ALK)融合基因首次被发现存在于部分非小细胞肺癌中。该融合基因是由2号染色体上2区1带和2区3带易位形成,可以诱导肿瘤生成,而ALK 抑制剂能够拮抗其促肿瘤生成活性。本文旨在介绍EML4-ALK基因阳性表达肺癌患者的临床特征及该基因在肺癌诊断、治疗中的意义。

Abstract: The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase(EML4ALK)fusion gene resulting from the chromosome inversion inv(2)(p21;p23)recently was identified in non-small cell lung cancer. EML4ALK fusion gene is oncogenic,which could be suppressed by ALK-inhibitor through blocking the downstream signaling pass-way of EML4-ALK. This review will focus on the clinicopathologic characteristics and targeted therapy of EML4-ALK in lung cancer.

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