EML4-ALK阳性表达非小细胞肺癌患者的临床特征及治疗现状

临床肿瘤学杂志

EML4-ALK阳性表达非小细胞肺癌患者的临床特征及治疗现状

孙霞，魏嘉，刘宝瑞

210008 南京南京医科大学鼓楼临床医学院南京大学医学院附属南京市鼓楼医院肿瘤中心

收稿日期:2012-08-03 修回日期:2012-09-28 出版日期:2013-01-31 发布日期:2013-01-31
通讯作者: 刘宝瑞

Clinicopathologic characteristics and treatment of non-small cell lung cancer with EML4-ALK fusion gene

SUN Xia，WEI Jia，LIU Baorui

Drum Tower Medical College of Nanjing Medical University，the Comprehensive Cancer Center，Drum Tower Hospital Affiliated to Medical School of Nanjing University，Nanjing 210008，China

Received:2012-08-03 Revised:2012-09-28 Online:2013-01-31 Published:2013-01-31
Contact: LIU Baorui

摘要/Abstract

摘要： 棘皮动物微管相关类蛋白4（EML4）与间变性淋巴瘤激酶（ALK）融合基因首次被发现存在于部分非小细胞肺癌中。该融合基因是由2号染色体上2区1带和2区3带易位形成，可以诱导肿瘤生成，而ALK 抑制剂能够拮抗其促肿瘤生成活性。本文旨在介绍EML4-ALK基因阳性表达肺癌患者的临床特征及该基因在肺癌诊断、治疗中的意义。

孙霞，魏嘉，刘宝瑞. EML4-ALK阳性表达非小细胞肺癌患者的临床特征及治疗现状[J]. 临床肿瘤学杂志, 2013, 18(1): 78-.

SUN Xia，WEI Jia，LIU Baorui. Clinicopathologic characteristics and treatment of non-small cell lung cancer with EML4-ALK fusion gene[J]. Chinese Clinical Oncology, 2013, 18(1): 78-.

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