Abstract: Objective To investigate the expressions of c-Myc and cyclin E protein in endometrial carcinoma and their association with clinicopathologic features. Methods The specimens from 15 normal endometrial tissue，30 atypical endometrial hyperplasia and 58 endometrial carcinoma were collected. Immunohistochemical methods were used to detect the expressions of c-Myc and cyclin E protein. ResultsThe postive rates of c-Myc protein in the normal endometrial，atypical endometrial hyperplasia and endometrial carcinomas tissues were 20.0％（3／15），73.3％（22／30）and 81.0％（47／58），respectively. The postive rates of cylin E protein in the normal endometrial，atypical endometrial hyperplasia and endometrial carcinomas tissues were 13.3％（2／15），56.7％（17／30）and 84.5％（49／58），respectively. The expression of c-Myc protein in endometrial carcinoma was associated with histologic grade，clinical stage，and the depth of myometrial tumor（P＜0.05）. There was no correlation between the expression of cyclin E protein and all of clinicopathologic characteristics. In the endometrial carcinoma， a positive relationship was found between the expressions of c-Myc and cyclin E protein. The differences between the expression of c-Myc and cyclin E protein in the low grade atypical endometrial hyperplasia and that of high grade atypical endometrial hyperplasia were statistically significant（P=0.021，P=0.002）. Conclusion c-Myc and cyclin E protein may cooperate in the occurrence and development of hormone dependent endometrial carcinoma. The abnormal expressions of c-Myc and cyclin E protein in the high grade atypical endometrial hyperplasia and endometrial carcinoma should be treated as one of screening indices of precancerous lesions.