Abstract: Objective To investigate technical points，effect and complications of fiducial implantation for body malignant solid tumors with cyberknife. Methods A total of 504 cases of body malignant solid tumors accepted fiducial implantation under CT guidance before the treatment of cyberknife. The complications and effect were observed. Results Among the 504 cases，the successful rate of fiducial implantation was 99.2％（500／504）. Among the 453 patients with liver nidi， 6 had fiducial migration. One hundred and fifty-eight patients felt pain at the punctured sites and 3 patients had tachycardia. Among the 19 lung cancer patients who accepted paracentesis，1 case had haemothorax and 1 case got pneumothorax. Conclusion The method of fiducial implantation on targets before treating malignant solid tumor with cyberknife is minimally invasive and comparatively safe.