Abstract: Billiary tract cancer is a group of heterogeneous disease，including extrahepatic cholangiocarcinoma，intrahepatic cholangiocarcinoma and gallbladder carcinoma. It has hidden onset，rapid progression，high degree of malignancy and poor prognosis，so multi-disciplinary treatment was emphasized. Medical treatment， including chemotherapy and molecular targeted therapy，has become one of the indispensable means. The results of UK ABC-02 clinical research laid the important position of gemcitabine and opened the door of drug treatment. This paper reviewed the current situation and research progress on the prognostic factors， neoadjuvant／adjuvant chemotherapy，palliative chemotherapy and molecular targeted therapy of billiary tract cancer.