Abstract:

Objective To explore the protein expression levels of EphB1 in ovarian serous adenocarcinoma and analyze its correlation with clinicopathological characteristics and prognosis. Methods The protein expression levels of EphB1 in 74 ovarian serous adenocarcinoma tissues were detected by immunohistochemical staining. The results were divided into low-level expression group（＜6）and high-level expression group（≥6）according to the immunohistochemical staining counting method. The relationship between expression of EphB1 and clinicopathological characteristics and prognosis was investigated. Results Out of 74 tissue samples of ovarian serous adenocarcinoma，67 cases were of positive expression（90.5％）and 7 cases were of negative expression（9.5％）, while low-level expression was in 32 cases（43.2％）and high-level expression in 42 cases（568％）. There were significant correlation between the expression of EphB1 and WHO grading，tumor diameter，metastasis, MDACC grade and Ki-67 index（P＜0.05）. No significant correlation existed between the expression of EphB1 and age，location，clinical stage and recurrence（P＞0.05）.There were no significant differences on 3-and 5-year survival rates between low-level expression group（both 68.3%）and high-level expression group（71.2% and 65.5%），but a downward trend was observed in low-level expression group compared with high-level expression group followed up over 6 years. Conclusion The EphB1 is positively expressed in ovarian serous adenocarcinoma tissue, mainly in high-level expression pattern. The protein expression of EphB1 is correlated with development and degree of differentiation in ovarian cancer，suggesting a role as a new indicator of prognosis in ovarian serous adenocarcinoma.