临床肿瘤学杂志

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14-3-3ζ和E-cadherin在Ⅲ期肺腺癌中的表达及其意义

刘潇莲,邢影,王校媛,孟庆威,蔡莉   

  1. 哈尔滨医科大学附属肿瘤医院内四科
  • 收稿日期:2014-07-20 修回日期:2014-09-18 出版日期:2014-11-30 发布日期:2014-11-30

Expressions of 14-3-3ζ and E-cadherin in stage Ⅲ lung adenocarcinoma and their clinical significance

LIU Xiaolian,XING Ying,WANG Xiaoyuan,MENG Qingwei,CAI Li.   

  1. The Fourth Department of Internal Medicine,Harbin Medical University Cancer Hospital,Harbin 150040,China
  • Received:2014-07-20 Revised:2014-09-18 Online:2014-11-30 Published:2014-11-30

摘要: 目的 检测Ⅲ期肺腺癌组织中1433ζ和E钙黏蛋白(Ecadherin)的表达,并探讨其临床意义。方法 采用免疫组化SP法检测59例Ⅲ期肺腺癌组织和43例正常肺组织中14-3-3ζ与E-cadherin蛋白的表达水平,分析两者表达的相关性以及与临床病理特征和预后的关系。
结果 14-3-3ζ在Ⅲ期肺腺癌组织中的高表达率为57.63%(34/59),高于正常肺组织的30.23%(13/43),差异有统计学意义(P<0.05);E-cadherin在肺腺癌组织中的高表达率为67.79%(40/59),低于正常肺组织的72.09%(31/43),差异无统计学意义(P>0.05)。2种蛋白的表达均与肺腺癌的分化程度相关(P<0.05)。Ⅲ期肺腺癌中14-3-3ζ与E-cadherin的表达呈显著正相关(r=0.351,P=0.015)。全组患者的中位生存时间(OS)为29.90个月。14-3-3ζ、E-cadherin高表达患者的中位OS均为52.63个月,优于低表达者的16.93个月(P<0.05)。Cox多因素分析显示,14-3-3ζ是Ⅲ期肺腺癌预后的独立影响因素(HR=0.345,95%CI:0.153~0.777,P=0.010)。结论 14-3-3ζ与E-cadherin在Ⅲ期肺腺组织中的表达呈现较好的相关性,检测二者的表达对判断Ⅲ期肺腺癌患者的预后有一定提示作用。

Abstract: Objective To investigate the expressions of 14-3-3ζ and E-cadherin in resected stageⅢ lung adenocarcinoma and their clinical significance.
MethodsThe expressions of 14-3-3ζ and E-cadherin in resected stage Ⅲ lung adenocarcinoma tissues obtained from 59 patients and 43 specimens of corresponding adjacent normal alveolus tissues using immunohistochemistry,and their correlations with clinicopathological characteristics and prognosis of patients were analyzed. The overall survival(OS) of patients was estimated using the KaplanMeier method. The factors affecting the prognosis of stage Ⅲ lung adenocarcinoma patients were analyzed by Cox multivariate survival analysis. ResultsThe high-level expression rate of 14-3-3ζ in lung adenocarcinoma tissue was 57.63%(34/59), higher than 30.23(13/43) of paired adjacent normal alveolus tissues with statistical difference(P<0.05). The high-level expression rate of E-cadherin in lung adenocarcinoma tissue was 67.79%(40/59), lower than 72.09%(31/43) of paired adjacent normal alveolus tissues without statistical difference(P>0.05). Both of 14-3-3ζ and E-cadherin expressions were correlated to differentiation(P<0.05).Positive correlation was observed between expressions of 14-3-3ζ and E-cadherin (r=0.351,P=0.015).The median OS of 59 patients was 29.90 months. The median OS of patients with 14-3-3ζ and E-cadherin high-level expression both were 52.63 months, higher than 16.93 months of patients with lowlevel expression(P<0.05). Multivariate survival analysis showed that 14-3-3ζ was independent prognostic indicator for resected stage Ⅲ lung adenocarcinoma patients(P<0.05). Conclusion The expressions of 14-3-3ζ and E-cadherin shows a good correlation in lung adenocarcinoma tissues. Detecting the expressions of these two proteins may give a clue on prognosis in patients with stageⅢ lung adenocarcinoma.

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