Abstract: Objective To investigate the expression of CC chemokine receptor 4（CCR4） in tumor infiltrating lymphocytes（TILs） of T1 stage lung adenocarcinoma and analyze its correlation with clinicopathological characteristics and prognostic impact. Methods The expression of CCR4 in TILs was quantified by tissue microarray and immunohistochemistry in 185 T1 stage adenocarcinomas. The relationship between the expression of CCR4 in TILs with clinicopathological characteristics and prognosis was analyzed. Results The expression of CCR4 was located in the nucleus of lymphocytes， with a positive expression ratio of（17.8±7.3）％. And patients were devided into high expression group and low expression group according 17.8%. The CCR4 expression was correlated with T stage， nodal involvement， lymphovascular invasion， and relapse（P＜0.05）， but not with age， gender or smoking history（P＞0.05）. The 5year overall survival rate of CCR4 was 88.1％， lower than that of CCR4 low expression group（89.8％） with statistically significant difference（P=0038）. The 3-year overall survival rates of CCR4 high expression group and low expression group were 98.7％ and 88.1％， the 5-year overall survival rates were 89.8％ and 88.1％，and the 8year overall survival rates were 86.6％ and 51.6％，with statistical significance（P＜0.05）；The 3-year recurrence-free survival rates of CCR4 high expression group and low expression group were 93.3％ and 82.3％， 3-year recurrencefree survival rates were 86.4％ and 74.5％， and 8-year recurrencefree survival rates were 83.4％ and 50.5％ with statistical significance（P＜0.05）. Conclusion The expression of CCR4 in TILs significantly increases with the aggression of lung adenocarcinoma and lymph node metastasis， indicating that it may be a predictor of prognosis and therapeutic target in patients with lung adenocarcinoma.