Abstract: Objective To investigate the expression of pokemon in ovarian caner and its relationship with clinicopathological characteristics.Methods The immunohistochemical method was used to detecte the expression of pokemon in 50 ovarian cancer tissues. The relationship between the expression of pokemon and clinicopathological characteristics （age， clinical stage， histological grade and lymph node metastasis） were evaluated in this study. The 20 borderline ovarian tumor tissues and 20 normal ovarian tissues of the same period were chosen as control.Results The positive expression of pokemon was located in the nucleus and cytoplasm. The positive expression rate of ovarian cancer was higher than those of borderline ovarian tumors and normal ovarian with significant difference （P＜0.05）. There was a higher positive expression rate in borderline ovarian tumor than that in normal ovarian （P＜0.05）. The positive expression rates of pokemon in ovarian cancer statistically varied among different clinical stage， histological grade and lymph node metastasis （P＜0.05）. Conclusion There was a high expression rate of pokemon in ovarian cancer， which was related to clinical stage， lymph metastasis and histological grade. Pokemon plays an important role in occurrence and development of ovarian cancer.