Abstract: Objective To investigate the value of using autofluorescence bronchoscopy（AFB） for the detection and localization of central type early lung cancer. Methods 93 patients，suspected of lung cancer were examinated by AFB and white light bronchoscopy（WLB）. All of the suspicious abnormal sites were recorded and biopsied for pathological examination. Two methods were compared by sensitivity and specificity. Results Included 93 biopsy specimens，and 74 were classified as positive by pathology，including 70 invasive cancer，1 carcinoma in situ and 3 severe dysplasia. AFB combined with WLB found positive resuts comfirmed by pathology in 67 cases, and WLB alone found positive in 50 cases. The relative sensitivity to detect central type early lung cancer of WLB combined with AFB versus WLB alone was 90.5％ and 67.6％, respectively，with statistical difference significantly（P＜0.05）. Conclusion The sensitivity of AFB is better than WLB in detection and localization of central type early lung cancer.