hPTTG1与肿瘤发生发展的研究进展

临床肿瘤学杂志

hPTTG1与肿瘤发生发展的研究进展

高英杰，杨娟，张超，韩竞春

116021 辽宁大连大连大学附属新华医院肿瘤科

收稿日期:2013-11-06 修回日期:2014-02-09 出版日期:2014-05-31 发布日期:2014-05-31
通讯作者: 韩竞春

The research progress of hPTTG1 in the occurrence and development of tumors

GAO Yingjie，YANG Juan，ZHANG Chao，HAN Jingchun.

Department of Oncology， Xinhua Hospital of Dalian University，Dalian 116021，China

Received:2013-11-06 Revised:2014-02-09 Online:2014-05-31 Published:2014-05-31
Contact: HAN Jingchun

摘要/Abstract

摘要： 人垂体瘤转化基因（hPTTG）是一种潜在的癌基因，自发现以来一直是研究的热点，在人体肿瘤中主要表达hPTTG1，且在多种肿瘤中高表达。研究证实，hPTTG1具有促进细胞转化、血管生成及肿瘤转移等生物学功能，在肿瘤的发生、发展、侵袭、转移及复发中起重要作用。hPTTG1对肿瘤的诊断具有重要的参考价值，有望成为肿瘤基因治疗的新靶点。

Abstract: As a potential oncogene， human pituitary tumor transforming gene（hPTTG） has been always the research foucs since it was discovered. hPTTG1 is mainly expressed in human tumors and highly expressed in a variety of tumors. Related studies have shown that hPTTG1 has the function of promoting cell transformation， angiogenesis, tumor metastasis and other biological functions. Besides, it plays an important role in tumorigenesis，occurrence，development，invasion， metastasis and recurrence of tumors. hPTTG1 has important reference value for diagnosis of tumor， and it represents potential target for gene therapy of tumor.

高英杰，杨娟，张超，韩竞春

. hPTTG1与肿瘤发生发展的研究进展[J]. 临床肿瘤学杂志, 2014, 19(5): 469-.

GAO Yingjie，YANG Juan，ZHANG Chao，HAN Jingchun.
. The research progress of hPTTG1 in the occurrence and development of tumors[J]. Chinese Clinical Oncology, 2014, 19(5): 469-.

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