Abstract: Objective To observe the curative effect and side effects of continuous infusion chemotherapy via superficial temporal artery on the maxillary malignant tumors. Methods Sixteen patients with unresectable advanced maxillary malignant tumor were enrolled in this study. After implantation of catheter into the superficial temporal artery， the patients received corresponding chemotherapy drugs via micro-infusion pump of drug pool at distal end of the catheter. The chemotherapy drugs were used as follow： docetaxel 60-75mg／m2， uniform perfusion for 2h， d1； cisplatin 75mg／m2， high dose pulse for 2h， d1； fluorouracil 500mg／m2， continuous infusion for 120h， d1-d5； pirarubicin 25mg／m2， uniform perfusion for 2h， d1-d3； gemcitabine 1000mg／m2， infusion for 30min， d1， d8. Twenty-one days was a cycle. The RECIST 1.1 and NCI CTC 3.0 criteria were employed to evaluate short-term effect and adverse reaction after two cycles. The patients were followed up for long-term survival. Results All patients were evaluable with 1 case of CR， 10 of PR and 5 of SD. The RR（CR+PR） and DCR（CR+PR+SD） were 68.8％ and 100.0％. In 14 cases（87.5％） followed up， the median overall survival and progression-free survival were 26.0 and 4.0 months， respectively. No treatment-related deaths and grade 4 toxicities were observed. The common grade 3 toxicities include 1 case of ear necrosis，3 cases of anemia and 1 case of bone marrow suppression. The rest were all grade 1-2.
ConclusionThe treatment of unresectable advanced maxillary malignant tumor of continuous infusion chemotherapy via superficial temporal artery had satisfying effect with tolerable side effects.