Abstract: Objective To explore the method of C arm CT imaging and its application range in transarterial chemoembolization （TACE） therapy for hepatocellular carcinoma （HCC） patients. Methods Eghity HCC patients receiving TACE therapy in our hospital during Sep. 2102 and Mar. 2013 were enrolled in the study. C arm CT imaging was applied during TACE therapy to guide TACE manipulation and assess its efficacy，thus to investigate C arm CT imaging method and assess its application range. Results In TACE therapy for HCC patients，using diluted non-ionic contrast agent in C arm CT imaging and taking arterial images in unenhanced phase， early phase and parenchymal phase can meet the needs of detecting carcinoma and displaying feeding artery， abnormal feeding artery and abnormal travelling artery. Therefore， we can assess survived carcinoma， lipiodol deposition conveniently， accurately and comprehensively as well as whether the feeding artery is embolized completely to evaluate the efficacy of TACE therapy. Carm CT scan didn’t significantly increase x-ray radiation dose， and mean operation time was prolonged by 9.5 minutes. ConclusionC arm CT is expected to be used safely and effectively. C arm CT imaging applied in TACE therapy for HCC patients will facilitate the design of therapeutic regimen before intervention， guiding of manipulation during intervention and immediate assessment after intervention.