Abstract:

MicroRNA （miRNA） is a kind of small endogenous non-coding single RNA containing 21-25 nucleotides， which regulates the expression of target genes through complementary binding to the 3’ untranslated region completely or incompletely. MiR-128， one of the subtypes of miRNA， expresses differently in a variety of diseases and normal tissues and plays an enormous role. Studies found that miR-128 played fundamental roles in various aspects of cellular function including differentiation， proliferation，migration and apoptosis in the development of several kinds of tumors including glioma， leukemia， stomach cancer， lung cancer and breast cancer. In this review， we will articulate the relationship between miR-128 and cancers， hoping to provide a new target for the treatment of tumor.