Abstract: Objective To investigate the imaging features of extrahepatic bile duct carcinoma with the real-time contrast-enhanced ultrasonography（CEUS） and contrast-enhanced MRI（CEMRI）. Methods A retrospective analysis was made on the imaging features in 56 patients with extrahepatic bile duct carcinoma in our hospital from January 2009 to December 2013， who were confirmed by pathology and examined by CEUS and CEMRI. Results As for CEUS， most of extrahepatic bile duct carcinoma lesions were hyper-enhanced（37／56，66.0％） in arterial phase， and hypo-enhanced in portal（50／56，89.3％） and late phase（56／56，100％）；when at peaking， 34 lesions（34／56） showed diffuse heterogeneous enhancement， and 22（22／56） showed homogeneous enhancement. As for CEMRI， most of extrahepatic bile duct carcinoma lesions were hyper-enhanced（37／56，66.0％） in arterial phase， iso-enhanced（29／56，51.7％） in portal phase and iso-enhanced（17／56，30.3％）or hyper-enhanced（33／56，58.9％）in late phase； when at peaking， 39 lesions（39／56） showed diffuse heterogeneous enhancement， and 17（17／56） showed homogeneous enhancement. The difference of lesion enhancment in arterial phase between CEUS and CEMRI was not sianificant（P＞0.05）. But there was a significant difference between CEUS and CEMRI on lesion enhancement in portal and late phase（P＜0.05）; there was no significant difference between CEUS and CEMRI on the number of the lesions showing diffuse homogeneous or heterogeneous enhancement（P＞0.05）. Conclusion Compared with CEMRI， CEUS can observe real-time micro perfusion of extrahepatic bile duct carcinoma.For the patients who were highly suspected of extrahepatic bile duct carcinoma， CEUS combined with CEMRI can provide an important imaging evidence for the diagnosis of extrahepatic bile duct carcinoma.