Abstract: The high mobility group protein A（HMGA） family is composed of four proteins. HMGA2 is one of the family. HMGA2 involves in epithelialmesenchymal transition， and plays a crucial role in maintaining the differentiation potential and the selfrenewal of neural stem cells（NSCs）.HMGA2 is able to process a number of different mechanisms involved in the regulation of biological events. Overexpression of HMGA2 has been observed in a variety of malignant tumors and often correlates with poor prognosis. In this review, we summarize the latest progresses on HMGA2 in cancer.