Abstract: Myeloidderived suppressor cells（MDSCs）is a crowd of cells， which can suppress the immune response， mainly by inhibiting T cells function， as a result， contributing to the genesis and development of disease. With the increasing importance of MDSCs as targets for treatment of cancer， more and more people have given considerable attention to it， and have achieved certain results. In this paper we reviewed the MDSCs immunosuppressive mechanism， and the role of MDSCs as potential targets in animal experiments， as well as in clinical researches， aiming at offering new insights into the treatment of malignant tumor.