临床肿瘤学杂志

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长非编码RNA UCA1在肿瘤研究中的进展

陈刘炜1 综述,王朝霞2 审校   

  1. 1 210029 南京 南京医科大学第一临床医学院临床医学系 2 210011 南京 医科大学第二附属医院肿瘤科
  • 收稿日期:2015-08-17 修回日期:2015-09-17 出版日期:2016-01-31 发布日期:2016-01-31
  • 通讯作者: 王朝霞

Advance of long non-coding RNA UCA1 in tumors

CHEN Liuwei,WANG Zhaoxia   

  1. Department of Clinical Medicine,the First Medical College of Nanjing Medical University,Nanjing 210029,China
  • Received:2015-08-17 Revised:2015-09-17 Online:2016-01-31 Published:2016-01-31
  • Contact: WANG Zhaoxia

摘要:

近来研究发现,长非编码RNA尿路上皮癌胚抗原1(UCA1)在多种肿瘤组织(膀胱癌、胃癌、肝癌、卵巢癌等)中呈高表达,表现为原癌基因的功能,在肿瘤的发生、发展中起着关键性作用。UCA1作为一种新的生物标记,在肿瘤的诊断、治疗以及预后中具有重要作用。本文结合国内外最新报道对UCA1在肿瘤研究中的进展作一综述。

Abstract:

Recently,high expression of long non-coding RNA urothelial carcinoma antigen 1(UCA1)has been found in various human carcinomas(bladder urothelial carcinoma,gastric cancer,hepatocellular carcinoma,ovarian cancer,etc)acting as proto-oncogene. UCA1 is playing an important role in the development and progression of tumors. As a novel biological marker,it is indispensible during the process of diagnosis,therapy and prognosis. In this view,we summarize the latest progress,both domestic and overseas,on the advance of UCA1 in tumor research.

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