Abstract: Objective To explore the effects of lipiodol sequential embolization with the embosphere microspheres in treatment of liver cancer rupture. Methods From April 2012 to June 2015，62 patients with emergency liver cancer rupture in our hospital were randomly assigned to receive embolotherapy with lipiodol alone（simple group，n=31）or lipiodol sequential embolization with the embosphere microspheres（sequential group，n=31）. The rebleeding rate and serious complications rate were analyzed betweer both groups. Results Sixty-two patients had a successful hemostasis after embolotherapy. All patients were followed up for 6 to 12 months. The rebleeding rate was 0 in sequential group，significantly lower than 12.9％（4／31） of simple group（P＜0.05）. The incidence rates of serious complications were 3.2％（1／31） and 6.5％（2／31） in simple group and sequential group，and the difference was not statistically significant （P＞0.05）. Conclusion Lipiodol sequential embolization with the embosphere microspheres has reliable and safe effecacy for the treatment of liver cancer rupture with a rather low rebleeding rate.