Abstract: Objective To explore the clinicopathological characteristics of male breast cancer and the factors affecting prognosis. Methods Clinical data of 55 patients with histopathologically confirmed male breast cancer who received operation from January 1999 to May 2010 were enrolled. The survival curves were draw by Kaplan-Meier method. Log-rank test and Cox proportional harzard regression model were used for survival and prognostic analysis. Results The 5-year survival rate of the whole group was 61.8％. The 5-year survival rates for stage Ⅰ，Ⅱ，Ⅲ and Ⅳ were 75.0％,69.6％,45.4％ and 20.0％ with statistical difference（P＜0.05）. The 5-year survival rates for histological grade Ⅰ，Ⅱ and Ⅲ were 83.3％,67.5％ and 33.3％ with statistical difference（P＜0.05）. Single factor analysis showed that histological grade，T stage，lymph node's metastasis，TNM stage and radiotherapy significantly influenced the 5-year survival rate（P＜0.05）. Cox regression analysis showed that histological grade（HR=3.690，95％CI：1.476-9.225，P＜0.05）and TNM stage（HR=3.437，95％CI：1.447-8.163，P＜0.05）were dependent prognostic factors influenced the overall survival for male breast cancer. Conclusion Histological grade and TNM stage are dependent prognostic factors for male breast cancer. The diagnosis and treatment of male breast cancer remains to be further studied.