Abstract: Colon cancer is one of the most common gastrointestinal malignancy. In the past decade，the adjuvant therapy of colon cancer has made great progress. Although surgery is the mainstay of treatment in colon cancer，adjuvant treatment is also an important aspect of increasing disease-free survival and overall survival in patients with colon cancer. In patients with colon cancer who suffer radical surgery，approximately one-third of patients are with regional lymph node metastasis，and one-quarter of patients are not associated with regional lymph node metastasis，but they have high risk factors for recurrence. The role of adjuvant therapy is to eliminate cancer micrometastasis sediments，which can increase the chance of cancer recurrence. In this article, the duration of chemotherapy，how do patients with different clinical stages start adjuvant therapy，adjuvant therapy of elderly patients and international prevailing disputes about adjuvant therapy are reviewed.