临床肿瘤学杂志

• 论著 • 上一篇    下一篇

Fn14、p-JAK2和p-STAT3在食管鳞癌中的表达及其相关性

刘 凯1,2,李小飞1,张志培1,孙 盈1

  

  1. 1 710038 西安第四军医大学唐都医院胸腔外科2 712000 咸阳市中心医院胸外科
  • 收稿日期:2016-01-20 修回日期:2016-02-18 出版日期:2016-05-31 发布日期:2016-05-31
  • 通讯作者: 李小飞

The correlation and expressions of Fn14, p-JAK2 and p-STAT3 in esophageal squamous cell carcinoma

LIU Kai, LI Xiaofei, ZHANG Zhipei, SUN Ying.

  

  1. Department of Thoracic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xian 710038, China
  • Received:2016-01-20 Revised:2016-02-18 Online:2016-05-31 Published:2016-05-31
  • Contact: LI Xiaofei

摘要: 目的 检测信号分子JAK2/STAT3在食管鳞癌组织样本中的表达,并探讨成纤维细胞生长因子诱导14(Fn14)表达与JAK2/STAT3信号通路的相关性。方法 采用免疫组织化学法检测118例食管癌组织及配对正常食管黏膜组织中Fn14、p-JAK2和p-STAT3蛋白的表达情况。分析Fn14与p-JAK2、p-STAT3蛋白表达的相关性及三者表达与食管鳞癌临床病理特征的关系。结果 Fn14阳性表达主要定位于细胞膜和胞浆,p-JAK2、p-STAT3阳性表达主要定位于细胞质和胞核。Fn14、p-JAK2、p-STAT3在食管鳞癌中的阳性表达率分别为51.7%(61/118)、50.9%(60/118)、57.6%(68/118),均高于正常食管黏膜鳞状上皮组织的4.2%(5/118),差异有统计学意义(P<0.05)。Fn14、p-JAK2及p-STAT3蛋白表达与分化程度、TNM分期有关(P<0.05),而与性别、年龄均无关(P>0.05)。Fn14与p-JAK2、p-STAT3在食管鳞癌不同分化程度组织中及不同TNM分期中均呈正相关(P<0.05)。结论 Fn14、p-JAK2、p-STAT3在食管鳞癌中高表达,可能与食管鳞癌的发生、发展有关。

Abstract: Objective To investigate the role of Fn14 with JAK2/STAT3 pathway in esophageal squamous cell carcinoma(ESCC), and the expression of JAK2/STAT3 molecules were detected and the correlation of Fn14 with JAK/STAT was discussed. Methods Fn14,p-JAK2 and p-STAT3 expressions in tumor tissues were assessed using immunohistochemical(IHC) methods in 118 patients with resected ESCC, and the correlation of Fn14 expression with JAK2/STAT3 expression was analyzed. Results The expression of Fn14 was mainly located on cell membrane and the expression of p-JAK2, p-STAT3 were mainly located in cytoplasm and cell nucleus. The positive expression rates of Fn14, p-JAK2 and p-STAT3 protein in ESCC were 51.7%(61/118), 50.9%(60/118) and 57.6%(68/118), which were higher than 4.2%(5/118) of corresponding adjacent non-cancerous tissue with statistical difference(P<0.05). There were significant differences for Fn14, p-JAK2, p-STAT3 expressions in pathological grades and TNM stages groups(P<0.05), while there were no significant differences for Fn14, p-JAK2, p-STAT3 in sex and age (P>0.05). The correlation of Fn14 with p-JAK2, p-STAT3 were obvious in pathological grades and TNM stages in ESCC(P<0.05). Conclusion The Fn14, p-JAK2, p-STAT3 proteins were highly expressed in ESCC, which suggest that Fn14, p-JAK2, p-STAT3 would be likely to be associated with the development of ESCC.

No related articles found!
Viewed
Full text
173
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 0 0 173

  From Others local
  Times 3 170
  Rate 2% 98%

Abstract
112
Just accepted Online first Issue
0 0 112
  From Others
  Times 112
  Rate 100%

Cited

Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!