Abstract: Objective To explore the effecacy and safety of S-1 plus compound kushen injection curative treatment for advanced gastric cancer. Methods Sixty-three elderly patients over the age of 70 with gastric cancer from the general hospital of shenyang military region were enrolled，excluding 4 patients of disease progression and fall off. Fifty-nine patients in total according to random number table method were divided into 28 cases as the control group and 31 cases as combined group. The control group was taken S-1 orally（40 mg/m2）， and combined group was taken S-1 plus compound kushen injection. The effecacy，adverse reactions and survival were observed. Results The response rate（RR）and disease control rate（DCR） of combined group were 549% and 903%， which were similar with 39.3% and 85.7% of the control group（P>0.05）. The main side effects were of grade 1-2 in both groups. The incidence of weakness and hepatic injury in combined group were 83.9% and 74.2%， lower than those in control group（100.0% and 96.4%）, respectively（P<0.05）. The median progression-free survival of combined group was 9.0 months， higher than 7.9 months in control group（P<0.05）. The median overall survival in combined group and control group was 14.6 months and 13.1 months（P>0.05）. ConclusionS-1 combined with compound kushen injection for the treatment of elderly advanced gastric cancer has a longer progression-free survival with slight adverse reactions，worthy of clinical promotion.