临床肿瘤学杂志

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长链非编码RNA PVT1在肿瘤中的研究进展

万里,马天云,王朝霞   

  1. 210011 南京 南京医科大学第二附属医院肿瘤科
  • 收稿日期:2015-07-25 修回日期:2015-11-29 出版日期:2016-06-30 发布日期:2016-06-30
  • 通讯作者: 王朝霞

Progression of long non-coding RNA PVT1 in tumor

WAN Li,MA Tianyun,WANG Zhaoxia   

  1. Department of Oncology,the Second Affiliated Hospital of Nanjing Medical University, Jiangsu Nanjing 210011,China
  • Received:2015-07-25 Revised:2015-11-29 Online:2016-06-30 Published:2016-06-30
  • Contact: WANG Zhaoxia

摘要: 长链非编码RNA(lncRNA)在肿瘤的发生、发展过程中起着重要作用。lncRNA PVT1在乳腺癌、肝细胞癌、胃癌、结肠癌等多种肿瘤中高表达,并发挥多种生物学功能,如竞争内源性RNA、维持重要癌基因蛋白的稳定性、参与肿瘤化疗耐药等。本文对lncRNA PVT1在肿瘤中的表达形式、所发挥的生物学功能及其分子机制作一综述。

Abstract: Long non-coding RNA(lncRNA) plays a significant role in tumor occurrence and development. Recent studies have found that lncRNA PVT1 was high expression in a wide variety of tumors(breast cancer, hepatocellular carcinoma, gastric cancer, colon cancer, etc.) and performed various biological functions, such as competing endogenous RNAs(ceRNAs), maintaining important oncogene protein stability,participating in tumor chemotherapy drug resistance. This paper reviews progression of lncRNA PVT1 expression, biological functions, molecular mechanism in tumor from the latest articles home and abroad.

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